Found insideVeterinary Toxicology for Australia and New Zealand is a reference suited to the unique challenges of veterinary practice in Australia and New Zealand. This book will take us on an expedition describing the role of ion channels in congenital and acquired diseases and the challenges and limitations scientist are facing in the development of drugs targeting these membrane proteins. Each section of the book includes an introduction based on the AP® curriculum and includes rich features that engage students in scientific practice and AP® test preparation; it also highlights careers and research opportunities in ... Found insideHowever, the real danger comes in the case of high concentrations and prolonged exposure to these species. This book presents an image of the mechanisms of action of reactive species and emphasizes their involvement in diseases. Organized into five chapters, this book begins with the morphological and cytological observations on mitochondria, and proceeding through membrane and matrix functions to participation in metabolism and biogenesis. The final section describes the commercially available enzymes, coenzymes, substrates, and several less common reagents. Biochemists, biophysicists, researchers, and graduate students will find this book extremely useful. Neurotoxicity of Pesticides, Volume Four, in this comprehensive serial addresses contemporary advances in neurotoxicology of pesticides by providing authoritative review articles on key issues in the field. Found insideWater quality monitoring is a fundamental tool in the management of freshwater resources, and this book covers the entire monitoring process providing detailed guidance for implementing a monitoring network with step-by-step descriptions of ... The second edition of the Encyclopedia of Toxicology continues its comprehensive survey of toxicology. This new edition continues to present entries devoted to key concepts and specific chemicals. Found inside – Page 463... MPTP (1-methyl-4-phenyl-1,2,3,6tetrahydropyridine) and rotenone affect complex I, while antimycin A1 inhibits complex III. Electron transfer is coupled ... Explores all ares of neurological sciences with over 1,000 entries on a wide variety of topics in neurology, neurosurgery, psychiatry and the related neuroscience. This book serves as an essential resource for both clinicians interested in the science being generated with animal models and basic scientists studying the pathogenesis of particular movement disorders. Extensively revised, the fourth edition of this highly successful book takes into account the many newly determined protein structures that provide molecular insight into chemiosmotic energy transduction, as well as reviewing the explosive ... Found insideThis book will, therefore, be essential for readers who are interested in life sciences, especially in medicine. This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism. Found inside – Page 306Rotenone and related compounds inhibit the mitochondrial electron transport chain by specific binding at a locus near the juncture of NADH dehydrogenase and ... Plant cell structure and function; Gene expression and its regulation in plant cells; The manipulation of plant cells. The chapters in this book explore topics such as high-resolution fluorespirometry and OXPHOS protocols in human cells, analysis of mitochondrial oxygen consumption, mitochondrial bioenergetics, and mitochondrial dynamics in mammalian cells. Found insideThis book does not strive to be comprehensive but instead offers a quick overview of principle aspects of toxins and toxicants in order to familiarize the key principles of toxicology. This edition features many new full-color images, additional coverage of pediatric disorders, updated Parkinson information, and many other valuable updates. Beginning with overviews of complexity of mitochondrial and nuclear genome disorders, the book continues with a section devoted to current biochemical protocols and a part focused on the DNA-based approaches used to identify molecular ... Written by experts in the field, this important guide provides easy access to current methods and techniques for the study of D. discoideum. This book contains 12 chapters divided into two sections. This new edition of Bioenergetics presents a clear and up-to-date explanation of the chemiosmotic theory and covers mitochondria, bacteria, and chloroplasts. Found insideThis book provides a thorough review of the mechanisms by which oxidative stress and redox signalling mediate Parkinson’s Disease. At present, there are several neuroprotective therapies in the experimental pipeline, but these are for the patients of tomorrow. This book focuses on two therapies that are readily available for the patients of today. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models ... This first volume starts with an overview on current perspectives in genetic research and on the molecular mechanisms of neurodegeneration. The 2nd edition of this popular book represents the collective wisdom of leading contributors worldwide and continues to fill an undeniable need in the literature relating to veterinary toxicology. Due to that at present, the majority of diseases are associated with alterations in oxidative stress and inflammatory processes, and in that Nrf-2 is a modulator of these processes; knowing how this transcriptional factor functions and is ... Found insideThese bacteria are of major importance for biotechnology, medicine, and agriculture. In this book, we present the experience of worldwide specialists in the field of Actinobacteria, exploring their current knowledge and future prospects. Found inside – Page 40GPRIN3 mRNA was significantly upregulated in response to a potent inhibitor of complex I in the electron transport chain of mitochondria, rotenone has been ... Found insideThe current book entitled Free Radicals, Antioxidants, and Diseases gives an idea of detecting free radicals in vivo by newer techniques and provides insights into the roles played by various antioxidants in combating diseases caused by ... Found inside – Page 327For example, inhibition of the electron transport chain (rotenone as an ... However, BPTES does not affect TCA cycle flux or activity of the electron ... Found inside – Page 53... NADH by the rotenonesensitive complex I of the electron - transport chain ... whereas the rotenone - insensitive bypass does not generate a pmf and is ... Found insideThis book comprised of three sections that focus various aspects of fungicide usages and its consequences. This book consists of an introductory overview of secondary metabolites, which are classified into four main sections: microbial secondary metabolites, plant secondary metabolites, secondary metabolites through tissue culture technique, and ... Found insideThe Scientists Guide to Cardiac Metabolism combines the basic concepts of substrate metabolism, regulation, and interaction within the cell and the organism to provide a comprehensive introduction into the basics of cardiac metabolism. 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